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    Biochemical Engineering Area

    Professor OMASA Takeshi   Associate Professor KOGA Yuichi
    Biochemical engineers are required to possess an integrated knowledge of governing biological properties and principles of chemical engineering methodology and strategy. We deal with the design, operation and optimization of bioprocesses concerned with the production of biological product by microbial and mammalian cells, including up- and down-stream processing working with industries.
    Current topics are mammalian and microbial cell and cell culture engineering for the production of biologics. Target biologics are enzymes, cytokines, therapeutic antibodies, vaccines and stem cell for cell therapy and drug evaluation.

    Bioresource Engineering Area

    Professor FUKUSAKI Eiichiro   Associate Professor SHIMMA Shuichi   Assistant Professor SASTIA PRAMA PUTRI
    In a turn of the century, environmental, food and energy problems are becoming more inevitable. Now is the time to develop an environmentally friendly and sustainable socialsystem; biotechnology plays a key role in this challenge. Bioresource Engineering is a technology in search of a “core biological agent”, and to evaluate its practicality. Our laboratory challenges the issues utilizing metabolomics and imaging mass spectrometry as our core competence. Our mission is to raise human resources, who will be the international leaders of the Biotechnology field.

    Molecular Genetics Area

    Associate Professor SUGIYAMA Minetaka   Assistant Professor SASANO Yu
    The major goal of our lab is to understand the genome function of yeasts including Saccharomyces cerevisiae. Because yeasts are not only eukaryotic organisms that share basic cellular processes with us but also important microorganisms for brewing and fermentation, elucidation of the genome functions is very advantageous for promoting both Bioscience and Biotechnology. Our current research focuses on genome wide study of stress resistant genes and its application to fermentation biotechnology and development of novel genome engineering technology and its application to functional genomics.

    Bioenvironmental Science Area

    Professor WATANABE Hajime   Associate Professor MATSUURA Tomoaki   Assistant Professor KATO Yasuhiko
    Many chemicals have been released into the environment in our modern society. However, despite much concern about possible harmful effects of the chemicals, their actual biological effects on humans and wildlife remain unclear. Our laboratory studies the biological responses elicited by environmental chemicals and is also establishing a new system for detecting chemicals using biological materials.

    Dynamic Cell Biology Area

    Associate Professor UCHIYAMA Susumu
    Chromosome is organized by DNA which encodes our genomic information, and it has been more than 100 years since the discovery of chromosome. However, the higher order structure of chromosome has not been elucidated. Our laboratory aim to elucidate the higher order structure using latest protein analysis and imaging techniques. Furthermore, we are also trying to establish a new technical approach by combination of nanotechnology and biology.

    Cell Technology Area

    Professor MURANAKA Toshiya   Associate Professor SEKI Hikaru   Assistant Professor FUKUSHIMA Ery Odette
    Plants produce a huge variety of specialized metabolites with different biological activities. Our primary interest is to understand the regulation and the synthesis of these compounds in plants identifying the genes involved in its biosynthesis and producing them using genetically modified organisms (bacteria, yeast, algae and model plants). More recently, we are promoting the study of valuable crops in a changing environment by combining genomics, metabolomics and genome editing technologies. Our goals and findings may contribute to promote health and increase food production in a climate-changing world.

    Synthetic Bioengineering area

    Associate Professor HONDA Kohsuke   Assistant Professor OKANO Kenji
    Bioproduction is a technology using enzymes and living organisms for the production of foodstuff, pharamaceuticals, and commodity chemicals. Our research has focused on the development of novel bioproduction processes.

    Bioprocess Systems Engineering Area

    Professor KINO-OKA Masahiro   Associate Professor KIM Mie-Hae
    Toward to ”Stem Cell Industries〞. Our missions are (1) to bring a good fortune in human life through the elucidation and utilization of ”bio-potential〞 by
    understanding sequential biological events (BioProcess) in the reaction field (Systems), and (2) to develop human resources of biochemical engineers. Our targets are the analysis, simulation, forecasting and control of various bioprocesses related to mammalian cells, and establishing methodologies for the utilization and application the principles of such processes.

    Metabolic Engineering Area[Graduate School of Information Science and Technology]

    Professor SHIMIZU Hiroshi   Associate Professor MATSUDA Fumio   Assistant Professor TOYA Yoshihiro
    In microbial cell factories creation for valuable compounds production, to improve increase production yield and productivity, we are trying to develop in silico design platform for molecular breeding and experimental evaluation system for cellular performance with 13C-based metabolic flux analysis. To create stress tolerant strains under sever conditions in bioprocesses, evolution engineering with multi-omics analysis is also performed.

    Symbiotic Network Design Area[Graduate School of Information Science and Technology]

    Associate Professor ICHIHASHI Norikazu   Assistant Professor TSURU Saburo
    Life is a network built up by a multitude of hierarchic components interacting with each other. For example, cells contain networks of various bio-molecules connected by biochemical reactions. On the upper level, there are ecological networks based on the interaction between individuals. We experimentally build up the artificial cells and artificial ecosystems which are simplified models for understanding the networks easily. We dream that the fundamental knowledge obtained from them could assist the design and application of a sustainable system. In addition, we aim to develop human resources who can design these systems.

    Molecular Microbiology Area[International Center for Biotechnology]

    Professor NIHIRA Takuya   Associate Professor KITANI Shigeru   Assistant Professor KINOSHITA Hiroshi
    "Laboratory of Molecular Microbiology" aims to pursue the huge potential of microorganisms by means of molecular biological methodology. Target microorganisms are Gram-positive soil bacteria Actinomycetes and filamentous fungi, both of which are representative two groups of microorganisms producing versatile kinds of natural bioactive compounds.We aim to develop quicker, easier and more rational way to reach novel bioactive compounds by clarifying biosynthetic pathways, functions of participating enzymes, obtaining regulatory genes and establishing multi-step signaling cascade controlling the whole biosynthetic pathway of bioactive secondary metabolites.

    Applied Microbiology Area[International Center for Biotechnology]

    Professor FUJIYAMA Kazuhito   Associate Professor MISAKI Ryo   Assistant Professor OHASHI Takao
    We are studying the development of human pharmaceutical protein production systems in various bioreactors such as plants, insects and microorganisms. Especially, we are focusing on the glycosylation that affects the drug efficacy. Our challenge is to produce human friendly-recombinant pharmaceutical proteins with basic glycoscience and glycoengineering.
    We are in progress toward discovery of microorganisms with new and remarkable potentials with the international cooperation among Southeast Asian countries in the aspects of research and educational advancement.

    Biomolecular Science and Engineering Area [Institute of Scientific and Industrial Research]

    Professor NAGAI Takeharu   Associate Professor MATSUDA Tomoki   Assistant Professor ARAI Yoshiyuki   Assistant Professor NAKANO Masahiro
    In order to understand principle how biological functions exert, which leads drug discovery or tailor-made medicine, information about spatiotemporal dynamics of each biomolecule is indispensable. To this end, our laboratory is developing genetically encoded indicators and new optical microscope systems.


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